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ObjectiveTo investigate the clinical features of acute myocardial infarction in CAPD patients.MethodsCompare the clinical and laboratory data of 39 patients with CAPD and AMI for the first time (PD group),including clinical symptoms,signs,electrocardiogram changes,myocardial enzyme changes and in hospital mortality,with those of 50 patients without renal insufficient but with AMI for the first time (C group).Diagnosis of AMI was made in hospital.ResultsCompared to C group, the symptoms presented at first in PD group were more atypical and the patients went to see doctor more lately after AMI.Atypical electrocardiogram changes were more in PD group than in C group (61.5% vs 26.0%,P
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AIM: To prepare polymethacrylate nanospheres and study the mechanism of breviscapine entrapped by polymethacrylate nanospheres. METHODS: Polymethacrylate nanospheres were prepared by microemulsion polymerization with SDS as surfactant, n-butanol as cosurfactant, MAA and BMA as monomer, TRIM as cross-linker and AIBN as initiator. Breviscapine added would be divided into two ways:prior to polymerization (encapsulation) and after polymerization (sorption), respectively. RESULTS: The size of the nanospheres was found to be 50nm by measuring with TEM. The ? potential of the nanospheres was -27.2 mv and it was increased after breviscapine being entrapped. The drug content entrapped in nanospheres was proportional to the drugs amount added in encapsulation method while the drug content in nanospheres was increased step by step in sorption method. CONCLUSION: The polymethacrylate nanospheres prepared by microemulsion polymerization could be applied to encapsulate hydrophobic traditional Chinese medicine extracts.
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AIM: To investigate the effect of peritoneal vibration on the peritoneal permeability and the peritoneal surface layer. METHODS: Peritoneal transport rate was examined in twelve male SD rats. Six (S group) were put on an electronic shaker and the other six were used as control (C group). After that, the peritoneum was examined by electron microscopy (EM). RESULTS: The net ultrafiltration volume (NUF) in the S group was lower than that in the C group. This difference in NUF was due to both a significantly higher peritoneal fluid absorption rate and a significantly lower transcapillary ultrafiltration rate in S group as compared to C group. The peritoneal direct lymphatic absorption rate was higher in S group. The transport rates of small solutes were also significantly higher in S group. EM showed that the thickness of the peritoneal surface layer was significantly decreased in S group. CONCLUSION: Our results suggest that the peritoneal surface layer may be an important layer in modulating the peritoneal transport rate.